Oncogenes

Publication Title: 
Experimental Cell Research

Lymphocytes have a finite and predictable proliferative life span in culture similar to that observed in fibroblasts. In general, the senescence of human fibroblasts is inevitable and irreversible, but their proliferative life span can be extended by certain DNA tumor virus oncogenes, such as the large T antigen of the SV40 virus. Here, we show that human T lymphocytes (HTL) can be stably transfected with SV40 large T and that expression of T antigen extended the life span of T cell cultures.

Author(s): 
Ryan, Q. C.
Goonewardene, I. M.
Murasko, D. M.
Publication Title: 
Mechanisms of Ageing and Development

An association between aging/longevity and cancer has long been suggested, yet the evolutionary and molecular links between these complicated traits remain elusive. Here, we analyze the relationship between longevity- and cancer-associated genes/proteins (LAGs/LAPs and CAGs/CAPs, respectively). Specifically, we address the following questions: (1) to what extent the CAGs and LAGs are evolutionary conserved and how they (or their orthologs) are related to each other in diverse species?

Author(s): 
Budovsky, Arie
Tacutu, Robi
Yanai, Hagai
Abramovich, Amir
Wolfson, Marina
Fraifeld, Vadim
Publication Title: 
Experimental Cell Research

Expression of the catalytic subunit of human telomerase, hTERT, extends human primary fibroblast life span. Such life span extension has generally been reported to be accompanied by net telomere lengthening, which led to the hypothesis that it is the telomere lengthening that causes the life span extension. Here we show that hTERT+C and hTERT-FlagC, mutant telomerase proteins with either 10 additional residues or a FLAG epitope added to the hTERT C-terminus, confer significant but limited life span extension to IMR90 human primary lung fibroblasts.

Author(s): 
Kim, Moses
Xu, Lifeng
Blackburn, Elizabeth H.
Publication Title: 
Blood

The pathogenesis of mycosis fungoides (MF), the most common cutaneous T-cell lymphoma (CTCL), is unknown. Although genetic alterations have been identified, none are considered consistently causative in MF. To identify potential drivers of MF, we performed whole-genome sequencing of MF tumors and matched normal skin. Targeted ultra-deep sequencing of MF samples and exome sequencing of CTCL cell lines were also performed. Multiple mutations were identified that affected the same pathways, including epigenetic, cell-fate regulation, and cytokine signaling, in MF tumors and CTCL cell lines.

Author(s): 
McGirt, Laura Y.
Jia, Peilin
Baerenwald, Devin A.
Duszynski, Robert J.
Dahlman, Kimberly B.
Zic, John A.
Zwerner, Jeffrey P.
Hucks, Donald
Dave, Utpal
Zhao, Zhongming
Eischen, Christine M.
Publication Title: 
Perspectives in Biology and Medicine

The benefits of apoptosis in the removal of unnecessary, damaged, or dangerous cells are dependent on the altruism resulting from the absence of genetic conflict between genes in cells. However, this altruism can be exploited by self-promoting or ultra-selfish genes. These self-promoting genes can be endogenous, as with neoplasia or germ cell mutations, or exogenous, as with cellular pathogens. The fundamental flaw of apoptosis is that its development and maintenance as a system is constantly opposed by the emergence of self-promoting genes.

Author(s): 
LeGrand, E. K.
Publication Title: 
Anticancer Research

Classical therapeutic modalities such as surgery, radiation and chemotherapy not only fail to cure the majority of neoplastic disease, but their employment also leads to severe and debilitating side effects. The severe cancer related morbidity is often associated with the use of radiation and chemotherapy, making them less than ideal forms of therapy.

Author(s): 
Bodey, B.
Siegel, S. E.
Kaiser, H. E.
Publication Title: 
Current Pharmaceutical Design

Classical therapeutic modalities such as surgery, radiation, and chemotherapy not only fail to cure the great majority of malignant tumors, but their employment often leads to severe and debilitating side effects. The severe cancer related morbidity is also in direct correlation with the use of x-radiation and chemotherapy, making them less than ideal forms of therapy.

Author(s): 
Bodey, B.
Bodey, B.
Siegel, S. E.
Kaiser, H. E.
Publication Title: 
Veterinary Pathology

Macaques provide an important animal model for the study of hormonal agents and their effects on risk biomarkers for breast cancer. A common criticism of this model is that spontaneous breast cancer has rarely been described in these animals. In this report, we characterize 35 mammary gland lesions ranging from ductal hyperplasia to carcinoma in situ and invasive ductal carcinoma in cynomolgus and rhesus macaques. Based on a retrospective analysis, we estimated the lifetime incidence of mammary gland neoplasia in aged female macaques to be about 6%.

Author(s): 
Wood, C. E.
Usborne, A. L.
Starost, M. F.
Tarara, R. P.
Hill, L. R.
Wilkinson, L. M.
Geisinger, K. R.
Feiste, E. A.
Cline, J. M.
Publication Title: 
Genes & Development

Metabolism generates oxygen radicals, which contribute to oncogenic mutations. Activated oncogenes and loss of tumor suppressors in turn alter metabolism and induce aerobic glycolysis. Aerobic glycolysis or the Warburg effect links the high rate of glucose fermentation to cancer. Together with glutamine, glucose via glycolysis provides the carbon skeletons, NADPH, and ATP to build new cancer cells, which persist in hypoxia that in turn rewires metabolic pathways for cell growth and survival.

Author(s): 
Dang, Chi V.
Subscribe to RSS - Oncogenes